Catecholamines Fractionated, 24-hour Urine

Overview

  • EPIC Code:
  • LAB373
  • Soft Test Code:
  • CATFU
  • Send Out Test Code:
  • 4646 | 318X
Alternate Names
  • Catecholamine Fractionated Urine
  • Catecholamine Fractionation, Urinary, Free
  • Catecholamines Fractionated, Free (w/out Creatinin
Included Tests

Dopamine, Epinephrine, Norepinephrine, Total Catecholamines (calculated)


Clinical Significance

Catecholamines, Fractionated, 24-Hour Urine (without Creatinine) [318X] - The three catecholamines (norepinephrine, epinephrine and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas and gangliomas) and with the evaluation of orthostatic hypotension


Specimen Collection & Preparation

Patient Preparation

Patient should avoid food high in indoles: Avocado, banana, tomato, plum, walnut, pineapple, and eggplant. Patient should also avoid tobacco, tea and coffee three days prior to specimen collection.


Specimen Requirements

10.0 mL aliquot from a well mixed 24 hour Urine Collection in (2) Plastic Vials


Alternate Specimen

10.0 (5.0) mL of a 24-hour random urine with 25 mL 6N HCl, submitted in a plastic, 24-hour urine container
Collect 24-hour urine with 25 mL 6N HCL to maintain a pH < or = 3. 

  • Preserved
  • Room temperature: 7 days
  • Refrigerated: 30 days
  • Frozen: 49 days



TransportAndStorage

Unpreserved
Unacceptable Ambient
30 days Refrigerated
49 days Frozen (Transport)


Collection Instructions

pH must be < = or 6. 

1. When starting the 24-hour period, urinate and discard (throw-away) this specimen. NOTE THE TIME
2. From that time on, collect all urine by urinating into a clean container and transfer into the provided container. 
DO NOT URINATE DIRECTLY INTO CONTAINER.
3. Try to pass the last urine just prior to the end of the 24 hour period. Add this urine into the container. 
4. Urine Specimen MUST be kept refrigerated during and after collection. 

For patient collection instruction sheet see Addendum D
For Spanish patient collection instruction sheet see Addendum D
For Burmese patient collection instruction sheet see Addendum D
For Arabic patient collection instruction sheet see Addendum D


Minimum Volume

5.0 mL Urine


Neonatal Volumne

Clinical Interpretation

Reference Range:

Norepinephrine

3-8 Years 5-41 mcg/24 h
9-12 Years 5-50 mcg/24 h
13-17 Years 12-88 mcg/24 h
>17 Years 15-100 mcg/24 h
Epinephrine
3-8 Years 1-7 mcg/24 h
9-12 Years ≤8 mcg/24 h
13-17 Years ≤11 mcg/24 h
>17 Years 2-24 mcg/24 h
Dopamine
3-8 Years 80-378 mcg/24 h
9-12 Years 51-474 mcg/24 h
13-17 Years 51-645 mcg/24 h
>17 Years 52-480 mcg/24 h
Total Catecholamines
3-8 Years 9-51 mcg/24 h
9-12 Years 9-71 mcg/24 h
13-17 Years 13-90 mcg/24 h
>17 Years 26-121 mcg/24 h


Methodology:
  • Electrochemical Detection
  • Kinetic Alkaline Picrate
  • Ultra Performance Liquid chromatography

Clinical Significance

Catecholamines, Fractionated, 24-Hour Urine (without Creatinine) [318X] - The three catecholamines (norepinephrine, epinephrine and dopamine) are the principal secretory products of neural tissue. Clinically, the measurement of circulating catecholamines is valuable in the diagnosis of catecholamine secreting tumors associated chiefly with hypertension (pheochromocytomas, neuroblastomas and gangliomas) and with the evaluation of orthostatic hypotension


Documentation

 Adrenaline,Noradrenaline,Catecholamines, Free


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

2 to 4 days


Coding & Compliance

CDM

01422773


CPT Coding

82384 CPT code 81050 may be added at an additional charge for volume measurement