Creatinine; Leukotriene E4
An aid to evaluate patients suspected of having systemic mastocytosis using 24-hour urine collections
5.0 mL Urine from a well mixed 24-hr Urine in a Plastic Vial
24 hours Ambient
7 days Refrigerated (Preferred)
30 days Frozen
No preservatives
1. When starting the 24-hour period, urinate and discard (throw-away) this specimen. NOTE THE TIME
2. From that time on, collect all urine by urinating into a clean container and transfer into the provided container.
DO NOT URINATE DIRECTLY INTO CONTAINER.
3. Try to pass the last urine just prior to the end of the 24 hour period. Add this urine into the container.
4. Urine Specimen should be kept refrigerated during and after collection.
Printable Patient Collection Instructions
English 24 Hour Urine Collection
Spanish 24 Hour Urine Collection
Burmese 24 Hour Urine Collection
Arabic 24 Hour Urine Collection
2.0 mL Urine
Leukotriene E4:
< or =104 pg/mg creatinine
Creatinine:
Normal values mg per 24 hours:
Males: 930-2955 mg/24 hours
Females: 603-1783 mg/24 hours
Elevated urinary leukotriene E4 (LTE4) concentrations greater than104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.
Urinary LTE4 may be used together with serum tryptase, urinary 2,3-dinor 11 beta-prostaglandin F2 alpha, and/or urinary N-methyl histamine
An aid to evaluate patients suspected of having systemic mastocytosis using 24-hour urine collections
Reference values have not been established for patients who are less than 18 years of age.
2 to 6 days
00913334
82542