Troponin T, 5th Generation

Overview

  • EPIC Code:
  • LAB3111
  • Soft Test Code:
  • TNT5
Clinical Significance

Troponin T is a regulatory protein released when cardiac cell necrosis occurs. It is not normally present in blood unless cardiac damage has occurred. Troponin T frequently appears in serum as early as one to three hours after the onset of myocardial infarction and remains elevated for 10 - 14 days. In cases of unstable angina and acute myocardial infarction with minimal cardiac damage, low elevations of CK and CK-MB are difficult to interpret; measurement of serum troponin T is a useful diagnostic aid in such patients


Specimen Collection & Preparation

Patient Preparation

Patient should discontinue taking Biotin, Vitamin B7, or Vitamin H 48 hours before getting blood drawn.


Specimen Requirements:

-OR-

1.0 mL Plasma in a PST Mint Green Top Tube - Li Heparin
Minimum Volume:
0.2 mL Plasma*

* This volume does not allow for repeat testing

Rejection Criteria:

Hemolysis

Serum


Transport and Storage:
  • Refrigerated (2-8°C): 24 Hours
  • Frozen (-20° C or colder): 12 Months

Clinical Interpretation

Reference Range:

Male:
 0 - 15 ng/L

Female:
 0-10 ng/L

Algorithm for use with Troponin T, Generation 5
To determine if a patient may have had a myocardial infarction, Troponin T, Generation 5 will be performed at zero and 2 hours.
 
If both the zero hour and 2-hour result is < 10 ng/L for women or < 15 ng/L for men and the 2-hour change is:
<4 ng/L
Cardiac injury is not indicated
> 4 ng/L and <10 ng/L
The result is abnormal.  Cannot rule out myocardial injury.  Repeat test in 2 hours.
> 10 ng/L
Suspicious for myocardial infarction (MI).  Recommend clinical correlation.
 
If either the zero hour or the 2-hour result is >10 ng/L for women or >15 ng/L in men and the 2-hour change is:
<4 ng/L
The result is abnormal.  Mostly suggestive of chronic myocardial injury or possible late MI.
> 4 ng/L and <10 ng/L
The result is abnormal.  Cannot rule out MI.  Repeat testing in 2 hours.
> 10 ng/L
Consistent with MI if clinical characteristics correlate.


Critical Ranges:

> 100 ng/L


Test Comments:

Patients taking vitamin supplements containing doses of >5 mg/day may have falsely decreased test results generated.


Methodology:
  • Electrochemiluminescence (ECLIA)
Clinical Significance

Troponin T is a regulatory protein released when cardiac cell necrosis occurs. It is not normally present in blood unless cardiac damage has occurred. Troponin T frequently appears in serum as early as one to three hours after the onset of myocardial infarction and remains elevated for 10 - 14 days. In cases of unstable angina and acute myocardial infarction with minimal cardiac damage, low elevations of CK and CK-MB are difficult to interpret; measurement of serum troponin T is a useful diagnostic aid in such patients


Production Schedule

Sites Performed
  • Parkview DeKalb Hospital
  • Parkview Huntington Hospital
  • Parkview Kosciusko Hospital
  • Parkview LaGrange Hospital
  • Parkview Noble Hospital
  • Parkview Randallia Hospital
  • Parkview Regional Medical Center
  • Parkview Southwest
  • Parkview Wabash Hospital
  • Parkview Whitley Hospital
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Chemistry
Turn Around Time

1 hour


Stat Eligible

Coding & Compliance

CDM

01424484


CPT Coding

84484