Thyroid Cascade Profile

Overview

  • EPIC Code:
  • MISC
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 330015
Included Tests

Thyroid-stimulating hormone (TSH)

Reflex testing:Thyroid Peroxidase (TPO) Ab; Thyroxine (T4) Free, Direct; Triiodothyronine (T3) Free; 

 


Clinical Significance

Aid clinicians in obtaining an appropriate diagnosis for common adult thyroid disorders. The cascade begins with a third-generation thyroid-stimulating hormone (TSH) test. If the TSH result is normal, a euthyroid status is assumed and testing stops. Additional testing is performed only if the initial TSH result is abnormally high or low. The cascade algorithm will select specific tests, based on the results of previously performed tests, which are necessary to arrive at the most appropriate laboratory diagnosis. The assayed value of a test, relative to the reference interval of that specific test, determines which, if any, additional tests are performed. The cascade proceeds, selecting specific tests, until the most probable diagnosis can be made.


Specimen Collection & Preparation

Test Notes

This profile is not intended for use in pediatric patients or in monitoring patients receiving treatment for thyroid disease with either ablative or suppressive therapy. It would also not be appropriate to use this procedure to diagnose primary thyroid neoplasm.


Patient Preparation

Patient should discontinue taking Biotin, Vitamin B7, Vitamin B8, Vitamin H, or coenzyme R 72 hours before getting blood drawn.


Specimen Requirements:

-OR-

2.0 mL Serum from a SST Gold Top Tube
Minimum Volume:
1.0 mL (Note: This volume does not allow for repeat testing.)(Note: This volume does not allow for repeat testing.)*

* This volume does not allow for repeat testing

Rejection Criteria:

Do not use oxalate

Do not use EDTA

Do not use citrate plasma


Transport and Storage:
  • Ambient: 14 Days
  • Refrigerated: 14 Days
  • Frozen (-20 C or colder): 14 Days

    Freeze/thaw cycles x3

Clinical Interpretation

Reference Range:

Refer to Interpretive Results


Test Comments:

Special reflexing. If TSH is <0.450, it will reflex to thyroxine (T4), free, direct and depending on the thyroxine (T4), free, direct result, may reflex to a triiodothyronine (T3), free, both at an additional charge. If the TSH is >4.500, it will reflex to thyroxine (T4), free, direct and depending on the thyroxine (T4), free, direct result, may reflex to a thyroid peroxidase (TPO) antibody,


Methodology:
  • Electrochemiluminescence (ECLIA)
Clinical Significance

Aid clinicians in obtaining an appropriate diagnosis for common adult thyroid disorders. The cascade begins with a third-generation thyroid-stimulating hormone (TSH) test. If the TSH result is normal, a euthyroid status is assumed and testing stops. Additional testing is performed only if the initial TSH result is abnormally high or low. The cascade algorithm will select specific tests, based on the results of previously performed tests, which are necessary to arrive at the most appropriate laboratory diagnosis. The assayed value of a test, relative to the reference interval of that specific test, determines which, if any, additional tests are performed. The cascade proceeds, selecting specific tests, until the most probable diagnosis can be made.


Production Schedule

Sites Performed
  • LabCorp
Departments
  • Sendouts - Miscellaneous

Coding & Compliance