LRP4 Autoantibody Test

Overview

  • EPIC Code:
  • LAB2639
  • Soft Test Code:
  • Send Out Test Code:
  • 94744
Alternate Names
  • LRP4
Clinical Significance

Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK


Specimen Collection & Preparation

Specimen Requirements

2.0 mL Serum from a SST Gold Top Tube


Transport And Storage

72 hours Ambient
25 days Refrigerated (Transport)
25 days Frozen


Collection Instructions

Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form


Minimum Volume

0.5 mL Serum


Neonatal Volume

Clinical Interpretation

Reference Range:

Refer to Interpretive Results


Methodology:
  • Immunofluorescence Assay (IFA)
Clinical Significance

Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK


Documentation

Disease test for: Myasthenia Gravis (MG)


Production Schedule

Sites Performed
  • Quest - Chantilly to Athena Labs
Departments
  • Sendouts - Clinical
Turn Around Time

9 to 16 days


Coding & Compliance

CDM

00918290


CPT Coding

86255