Chronic Lymphocytic Leukemia Prognostic Panel without Karyotype

Overview

  • EPIC Code:
  • MISC
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 17312
Alternate Names
  • Chronic Lymphocytic Leukemia Prognostic Panel w/ou
  • Chronic Lymphocytic Leukemia Prognostic Panel with
  • CLL Panel, w/out Karyotype
  • CLL Prognostic Panel w/out Karyotype
  • CLL Prognostic Panel without Karyotype
Included Tests

Beta-2-Microglobulin; CD38+/CD19+;  Chronic Lymphocytic Leukemia, IgVH Mutation Status, Cell-based; FISH, B-Cell Chronic Lymphocytic Leukemia Panel; ZAP 70


Clinical Significance

Chronic lymphocytic leukemia is the most common leukemia in the Western World. The disease is chronic and most patients may not require therapy in the early stage of the disease. However, in some patients the disease can be aggressive and within a year the tumor mass may increase significantly imposing serious health problems to the patient. It is difficult to determine based on clinical presentation which patient will progress faster than the others. Therefore there is a need to use more accurate prognostic indicator to predict the clinical course of this disease. The recent advances in CLL therapy and biology made it possible to develop new tests for predicting clinical behavior, such as ZAP 70, IgVH,...However, each individual test has its limitation and a combination of these tests (panel) provide more accurate information.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a Red Top Tube in a Plastic Vial 
and
5.0 mL Whole Blood in a Lavender Top Tube - EDTA 
and
16.0 mL Whole Blood in a Green Top Tube - Na Heparin


Alternate Specimen


TransportAndStorage

72 hours Ambient


Collection Instructions

Serum and EDTA whole blood and sodium heparin whole blood are required for this panel.


Minimum Volume

0.5 mL serum, 3 mL EDTA WB, 10 mL Na WB


Neonatal Volumne

Clinical Interpretation

Reference Range:

Refer to Interpretive Results


Methodology:
  • Flow Cytometry
  • Fluorescence in situ Hybridization (FISH)
  • Polymerase Chain Reaction (PCR)

Clinical Significance

Chronic lymphocytic leukemia is the most common leukemia in the Western World. The disease is chronic and most patients may not require therapy in the early stage of the disease. However, in some patients the disease can be aggressive and within a year the tumor mass may increase significantly imposing serious health problems to the patient. It is difficult to determine based on clinical presentation which patient will progress faster than the others. Therefore there is a need to use more accurate prognostic indicator to predict the clinical course of this disease. The recent advances in CLL therapy and biology made it possible to develop new tests for predicting clinical behavior, such as ZAP 70, IgVH,...However, each individual test has its limitation and a combination of these tests (panel) provide more accurate information.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Thursday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

10 to 11 days


Coding & Compliance

CDM

00913333


CPT Coding

88184, 88185 (x2), 81263, 82232, 88271 (x5), 88275(x5)