Clozapine & Norclozapine

Overview

  • EPIC Code:
  • LAB2562
  • Soft Test Code:
  • CLOZ
  • Send Out Test Code:
  • 1769
Alternate Names
  • Clozapine and Norclozapine
  • Clozaril
Included Tests

Clozapine; Norclozapine


Clinical Significance

Clozapine is an antipsychotic agent. Peak clozapine concentrations are reached in 1-6 hours following oral dosage. Elimination half-life is 4-16 hours once steady state levels have been reached. Norclozapine has minimal therapeutic activity


Specimen Collection & Preparation

Specimen Requirements

2.0 mL Serum from a Red Top Tube in a Plastic Vial

Alternate Specimen

2.0 mL Plasma from a Green Top Tube - Li Heparin in a Plastic Vial
or
2.0 mL Plasma from a Green Top Tube - Na Heparin in a Plastic Vial
or
2.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial

TransportAndStorage

30 days Ambient
30 days Refrigerated
30 days Frozen

Avoid using glass material for long-term storage as drug adsorbs on the glass.

Collection Instructions


Clinical Interpretation

Reference Range:

Norclozapine 25-400 mcg/L
Clozapine See Laboratory Report


Methodology:
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

Clozapine is an antipsychotic agent. Peak clozapine concentrations are reached in 1-6 hours following oral dosage. Elimination half-life is 4-16 hours once steady state levels have been reached. Norclozapine has minimal therapeutic activity


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 6 days


Coding & Compliance

CDM

00910392


CPT Coding

80159