Prostaglandin D2 (PG D2), Random Urine

Clinical Significance

Prostaglandins are fatty acids derived from arachidonic  acid metabolism.  They are closely related to the Thromboxanes and Leukotrienes.  Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin  D2.  Prostaglandin D2 is excreted directly into the urine.The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach.  Prostaglandin D2 is the major Prostaglandin produced by uterine tissue.  Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent.  It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have an anti-metastatic effect on many malignant tumor cells.   Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin.

Patient Preparation

Patient should not be on aspirin, indomethacin, or anti-inflammatory medications, if possible, for at least 48 hours prior to collection of specimen.

Reference Range:

Up to 175 ng/g Creatinine

Methodology:

• Direct ELISA

Clinical Significance

Prostaglandins are fatty acids derived from arachidonic  acid metabolism.  They are closely related to the Thromboxanes and Leukotrienes.  Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin  D2.  Prostaglandin D2 is excreted directly into the urine.The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach.  Prostaglandin D2 is the major Prostaglandin produced by uterine tissue.  Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent.  It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have an anti-metastatic effect on many malignant tumor cells.   Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin.

CDM

00913334

CPT Coding

84150