Copper, Urine

Clinical Significance

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Urinary copper concentrations are also useful to monitor patients on chealation therapy.

Specimen Requirements

7.0 mL aliquot from Urine collected in an Sterile Gray placed into a metal-free leak-proof container

Alternate Specimen

 

TransportAndStorage

5 days Ambient
7 days Refrigerated
28 days Frozen

Collection Instructions

 

Minimum Volume

3.0 mL Urine

Neonatal Volumne

Reference Range:

Copper, Random Urine

<87 mcg/g creatinine

Creatinine, Random Urine

≤6 Months	2-32 mg/dL
7-11 Months	2-36 mg/dL
1-2 Years	2-128 mg/dL
3-8 Years	2-149 mg/dL
9-12 Years	2-183 mg/dL
>12 Years
Male	20-370 mg/dL
Female	20-320 mg/dL

Methodology:

• Inductively Coupled Plasma / Mass Spectrometry (ICP/MS)

Clinical Significance

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes disease, primary biliary cirrhosis, and Indian childhood cirrhosis. Urinary copper concentrations are also useful to monitor patients on chealation therapy.

CDM

00913333

CPT Coding

82525, 82570