CNS Demyelinating Disease Evaluation

Included Tests

CNS Demyelinating Disease Interp; Myelin Oligodendrocyte Glycoprotein; Neuromyelitis Optica/Aquaporin-4-IgG
Reflex:  Myelin Oligodendrocyte Glycoprotein (MOG-IgG1) Fluorescence-Activated Cell Sorting (FACS) Assay; Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay

Client Notes:

For optimal antibody detection, we recommend blood drawing the specimen before initiation of immunosuppressant medication.

Specimen Requirements

3.0 mL Serum from a Red Top Tube in a Plastic Vial

Alternate Specimen

 

TransportAndStorage

72 hours Ambient
28 days Refrigerated 
28 days Frozen

Collection Instructions

 

Minimum Volume

Neonatal Volumne

Reference Range:

MOG FACS, S- negative (reference values apply to all ages);  NMO/AQP4 FACS, S- negative (reference values apply to all ages).

Test Comments:

When the results of this assay require further evaluation of myelin oligodendrocyte glycoprotein (MOG-IgG1), the MOG-IgG1 titer will be performed at an additional charge.  When the results of this assay require further evaluation of neuromyelitis optica (NMO)/Aquaporin-4-IgG, the neuromyeltis optica (NMO)/aquaporin-4-IgG titer will be performed at an additional charge. 

Methodology:

• Flow Cytometry (FC)

CDM

00917724; 00917723

CPT Coding

86053, 86363, 86053-titer (if appropriate), 86363-titer (if appropriate)