CNS Demyelinating Disease Evaluation

Overview

  • EPIC Code:
  • IMO5737
  • Soft Test Code:
  • CDS1
  • Send Out Test Code:
  • CDS1
Alternate Names
  • Aquaporin
  • Devic's Antibody
  • Neruomyelitis Optica (NMO)
  • Optic Neuritis Antibody
  • Transverse Myelitis Antibody
  • Vision Loss Antibody
Included Tests

CNS Demyelinating Disease Interp; Myelin Oligodendrocyte Glycoprotein; Neuromyelitis Optica/Aquaporin-4-IgG
Reflex:  Myelin Oligodendrocyte Glycoprotein (MOG-IgG1) Fluorescence-Activated Cell Sorting (FACS) Assay; Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay


Specimen Collection & Preparation

Client Notes:

For optimal antibody detection, we recommend blood drawing the specimen before initiation of immunosuppressant medication.


Specimen Requirements

3.0 mL Serum from a Red Top Tube in a Plastic Vial

Alternate Specimen

 

TransportAndStorage

72 hours Ambient
28 days Refrigerated 
28 days Frozen

Collection Instructions

 

Clinical Interpretation

Reference Range:

MOG FACS, S- negative (reference values apply to all ages);  NMO/AQP4 FACS, S- negative (reference values apply to all ages).


Test Comments:

When the results of this assay require further evaluation of myelin oligodendrocyte glycoprotein (MOG-IgG1), the MOG-IgG1 titer will be performed at an additional charge.  When the results of this assay require further evaluation of neuromyelitis optica (NMO)/Aquaporin-4-IgG, the neuromyeltis optica (NMO)/aquaporin-4-IgG titer will be performed at an additional charge. 


Methodology:
  • Flow Cytometry (FC)

Production Schedule

Sites Performed
  • Mayo Laboratory
Days Performed
Monday
Tuesday
Thursday
Departments
  • Sendouts - Clinical
Turn Around Time

7 to 10 days


Coding & Compliance

CDM

00917724; 00917723


CPT Coding

86053, 86363, 86053-titer (if appropriate), 86363-titer (if appropriate)