Copper

Overview

  • EPIC Code:
  • LAB817
  • Soft Test Code:
  • COPP
  • Send Out Test Code:
  • 363
Clinical Significance

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes diseases, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.


Specimen Collection & Preparation

Specimen Requirements:

-OR-

2.0 mL Plasma from a Navy Blue Top Tube - EDTA in a Acid Washed/Metal Free Plastic Vial
Minimum Volume:
0.7 mL plasma*

* This volume does not allow for repeat testing

Processing Instructions:

Centrifuge and separate plasma from cells within 2 hours of collection

Transfer plasma to an acid washed or metal-free plastic vial 


Rejection Criteria:

Hemolysis 

Not separated from cells

Submitted in non-trace metal container

Submitted in non acid washed container


Transport and Storage:
  • Ambient (18-24°C): 5 Days

    Transport 

  • Refrigerated (2-8°C): 10 Days
  • Frozen (-20° C or colder): 30 Days

Clinical Interpretation

Reference Range:

< 6 months:      38 - 104 mcg/dL
< 12 months:    24 - 152 mcg/dL
< 2 years:          76 - 193 mcg/dL
< 4 years:          87 - 187 mcg/dL
< 6 years:          56 - 191 mcg/dL
< 10 years:       117 - 181 mcg/dL
< 14 years:       87 - 182 mcg/dL
< 18 years:       75 - 187 mcg/dL

>= 18 years:    70 - 175 mcg/dL


Methodology:
  • Inductively Coupled Plasma / Mass Spectrometry (ICP/MS)
Clinical Significance

Copper is an essential element that is a cofactor of many enzymes. Copper metabolism is disturbed in Wilson's disease, Menkes diseases, primary biliary cirrhosis, and Indian childhood cirrhosis. Copper concentrations increase in acute phase reactions. Copper concentrations are decreased with nephrosis, malabsorption, and malnutrition. Copper concentrations are also useful to monitor patients, especially preterm newborns, on nutritional supplementation. Results of copper are often interpreted together with ceruloplasmin.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

1 to 2 days


Coding & Compliance

CDM

01423976


CPT Coding

82525