Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours
5.0 mL Whole Blood in a Lavender Top Tube - EDTA
5.0 mL Whole Blood in a Green Top Tube - Na Heparin
7 days Ambient
6 days Refrigerated
Optimum time to collect sample is 1 hour before dose (trough collecton)
2.0 mL Whole Blood
No definitive therapeutic or toxic ranges have been established. Opitmal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.
The following trough ranges are suggested guidelines:
| Kidney Transplantation | 100-200 mcg/L |
| Other Organ Transplant | 200-300 mcg/L |
Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours
1 to 2 days
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