Cyclosporine (1)

Overview

  • EPIC Code:
  • LAB7000
  • Soft Test Code:
  • CYCS
  • Send Out Test Code:
  • 15220
Alternate Names
  • Cyclosporine A Trough
Clinical Significance

 Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours


Specimen Collection & Preparation

Specimen Requirements

 5.0 mL Whole Blood in a Lavender Top Tube - EDTA

Alternate Specimen

 5.0 mL Whole Blood in a Green Top Tube - Na Heparin

TransportAndStorage

7 days Ambient 
6 days Refrigerated

Collection Instructions

 Optimum time to collect sample is 1 hour before dose (trough collecton)

Clinical Interpretation

Reference Range:

No definitive therapeutic or toxic ranges have been established. Opitmal blood drug levels are influenced by type of transplant, patient response, time post-transplant, co-administration of other drugs, and drug formulation.


Test Comments:

The following trough ranges are suggested guidelines:

Kidney Transplantation 100-200 mcg/L
Other Organ Transplant 200-300 mcg/L


Methodology:
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

 Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; Low levels can lead to organ rejection following transplant. Peak concentrations are reached at around 3.5 hours after oral dosage. Elimination half-life is 10-27 hours


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

1 to 2 days


Coding & Compliance

CPT Coding

80158