Aldosterone, LC/MS/MS

Overview

  • EPIC Code:
  • LAB557
  • Soft Test Code:
  • ALDOS
  • Send Out Test Code:
  • 17181
Clinical Significance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial

Alternate Specimen

1.0 mL Serum from a Red Top Tube in a Plastic Vial
or 
1.0 mL Plasma from a Green Top Tube - Na Heparin in a Plastic Vial
or 
1.0 mL Plasma from a Green Top Tube - Li Heparin in a Plastic Vial

TransportAndStorage

4 days Ambient
7 days Refrigerated
28 days Frozen

Collection Instructions

Separate serum after clotting. 

Draw Upright Specimens at least 1/2 hour after patient sits up

Clinical Interpretation

Reference Range:

Refer to Interpretive Results

 


Methodology:
  • Chromatography / Mass Spectrometry

Clinical Significance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body position, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.


Documentation

*Pediatric data from J Clin Endocrinol Metab. 1992;
75:1491 and J CLin Endocrinol Metab. 1989; 69:1133-1136.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 6 days


Coding & Compliance

CDM

01423200


CPT Coding

82088