17-Hydroxyprogesterone

Clinical Significance

17-Hydroxyprogesterone is elevated in patients with Congenital Adrenal Hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.

Specimen Requirements

0.5 mL Serum from a Red Top Tube in a Plastic Vial

Alternate Specimen

0.5 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial 
or
0.5 mL Plasma from a Navy Blue Top Tube - EDTA in a Plastic Vial 
or
0.5 mL Plasma from a Green Top Tube - Li Heparin in a Plastic Vial  
or 
0.5 mL Plasma from a Green Top Tube - Na Heparin in a Plastic Vial

TransportAndStorage

48 hours Ambient
7 days Refrigerated (Transport)
2 years Frozen

Collection Instructions

Separate serum after clotting. Ship serum refrigerated or frozen

Minimum Volume

0.25 mL Serum

Neonatal Volumne

Reference Range:

Adult Male
18-30 Years	32-307	ng/dL
31-40 Years	42-196	ng/dL
41-50 Years	33-195	ng/dL
51-60 Years	37-129	ng/dL
Adult Female
Follicular Phase	≤185	ng/dL
Luteal Phase	≤285	ng/dL
Postmenopausal	≤45	ng/dL
Pregnancy
First Trimester	78-457	ng/dL
Second Trimester	90-357	ng/dL
Third Trimester	144-578	ng/dL
Pediatric
1-12 Months	11-170	ng/dL
1-4 Years	4-115	ng/dL
5-9 Years	≤90	ng/dL
10-13 Years	≤169	ng/dL
14-17 Years	16-283	ng/dL
Infant
Premature (31-35 Weeks)	≤360	ng/dL
Term (3 Days)	≤420	ng/dL
Tanner Stages
II-III Male	12-130	ng/dL
II-III Female	18-220	ng/dL
IV-V Male	51-190	ng/dL
IV-V Female	36-200	ng/dL

Methodology:

• Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

17-Hydroxyprogesterone is elevated in patients with Congenital Adrenal Hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.

CDM

01422803

CPT Coding

83498