Ceruloplasmin

Overview

  • EPIC Code:
  • LAB703
  • Soft Test Code:
  • CERUL
  • Send Out Test Code:
  • 326
Alternate Names
  • Copper Oxide
  • Wilson's Disease
Clinical Significance

Decreased levels of ceruloplasmin are found in Wilson's Disease, fulminant liver failure, intestinal malabsorption, renal failure resulting in proteinuria, chronic active hepatitis and malnutrition. Elevated levels are found in primary biliary cirrhosis, pregnancy (first trimester), oral contraceptive use and in acute inflammatory conditions since ceruloplasmin is an acute phase reactant.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum in a SST Gold Top Tube


Alternate Specimen

 


TransportAndStorage

60 days Refrigerated (Preferred)
3 months Frozen


Collection Instructions

 


Minimum Volume

0.5 mL


Neonatal Volumne

Clinical Interpretation

Reference Range:

Male: 
0 days to 30 days: 8 - 25 mg/dL
31 days to 11 months: 15 - 48 mg/dL
1 year to 3 years: 25 - 56 mg/dL
4 years to 6 years: 29 - 56 mg/dL
7 years to 9 years: 25 - 52 mg/dL
10 years to 12 years: 21 - 51 mg/dL
13 years to 15 years: 20 - 50 mg/dL
16 years to 18 years: 20 - 45 mg/dL
Adult: 18 - 36 mg/dL

Female:
0 days to 30 days: 3 - 28 mg/dL
31 days to 11 months: 15 - 43 mg/dL
1 year to 3 years: 29 - 54 mg/dL
4 years to 6 years: 29 - 54 mg/dL
7 years to 9 years: 23 - 48 mg/dL
10 years to 12 years: 21 - 48 mg/dL
13 years to 15 years: 21 - 46 mg/dL
16 years to 18 years: 22 - 50 mg/dL
Adult: 18 - 53 mg/dL


Methodology:
  • Nephelometry

Clinical Significance

Decreased levels of ceruloplasmin are found in Wilson's Disease, fulminant liver failure, intestinal malabsorption, renal failure resulting in proteinuria, chronic active hepatitis and malnutrition. Elevated levels are found in primary biliary cirrhosis, pregnancy (first trimester), oral contraceptive use and in acute inflammatory conditions since ceruloplasmin is an acute phase reactant.


Documentation

Limitations: Since ceruloplasmin is an acute phase reactant, caution is necessary when inflammation or infection are present


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 6 days


Coding & Compliance

CDM

01425713


CPT Coding

82390