Aquaporin-4 Receptor Antibody by ELISA, with Reflex to AQP4 Receptor Antibody, IgG by IFA, Serum

Overview

  • EPIC Code:
  • MISC
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 2013327
Alternate Names
  • AQP4
  • Devic's Ab
  • Neuromyelitis Optica (NMO)
  • Neuromyelitis Optica (NMO) Antibody
  • Optic Neuritix Ab
  • Optic-Spincal MS Ab
  • Transverse Myelitis Ab
  • Vision Loss Ab
Clinical Significance

Approximately 75 percent of patients with neuromyelitis optica (NMO) express antibodies to the aquaporin-4 (AQP4) receptor. Diagnosis of NMO requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. While absence of antibodies to the AQP4 receptor does not rule out the diagnosis of NMO, presence of this antibody is diagnostic for NMO.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a SST Gold Top Tube

Alternate Specimen

1.0 mL Serum from a Red Top Tube in a Plastic Vial

TransportAndStorage

After separation of cells
72 hours Ambient
2 weeks Refrigerated
1 month Frozen

Collection Instructions

Mix by inverting tube 5 times.

Separate from cells ASAP or within 2 hours of collection

Clinical Interpretation

Reference Range:

Refer to Interpretive Results


Test Comments:

Reflexive Testing:
If AQP4 antibody IgG by ELISA is positive, then AQP4 antibody IgG by IFA will be added. If AQP4 antibody IgG by IFA is positive, then an AQP4 antibody IgG titer will be added. Additional charges apply.
Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum
REFLEX: Neuromyelitis Optica/AQP4-IgG Titer, Serum


Methodology:
  • IFA
  • Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Clinical Significance

Approximately 75 percent of patients with neuromyelitis optica (NMO) express antibodies to the aquaporin-4 (AQP4) receptor. Diagnosis of NMO requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. While absence of antibodies to the AQP4 receptor does not rule out the diagnosis of NMO, presence of this antibody is diagnostic for NMO.


Documentation

For evaluation of optic neuritis, acute myelitis, spinal cord lesions, or autoimmune encephalitis


Production Schedule

Sites Performed
  • ARUP Lab
Days Performed
Tuesday
Thursday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

2 to 7 days


Coding & Compliance

CDM

00913333


CPT Coding

86051