Alkaline Phosphatase, Bone Specific

Overview

  • EPIC Code:
  • LAB2939
  • Soft Test Code:
  • APBS
  • Send Out Test Code:
  • 29498
Alternate Names
  • Bone-Specific Alkaline Phosphatase
  • BSAP
Clinical Significance

The Bone-Specific Alkaline Phosphatase (BSAP) assay provides a general index of bone formation and a specific index of total osteoblast activity. BSAP and osteocalcin are the most effective markers of bone formation and are particularly useful for monitoring bone formation therapies and antiresorptive therapies.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a SST Gold Top Tube


Alternate Specimen

1.0 mL Serum from a Red Top Tube in a Plastic Vial


TransportAndStorage

7 days Ambient
7 days Refrigerated
60 days Frozen


Collection Instructions

Allow serum samples to clot completely before centrifugation


Minimum Volume

0.3 mL Serum


Neonatal Volumne

Clinical Interpretation

Reference Range:

Adult Male  
18-29 Years 8.4-29.3 mcg/L
30-39 Years 7.7-21.3 mcg/L
40-49 Years 7.0-18.3 mcg/L
50-68 Years 7.6-14.9 mcg/L
Adult Female  
18-29 Years 4.7-17.8 mcg/L
30-39 Years 5.3-19.5 mcg/L
40-49 Years 5.0-18.8 mcg/L
50-76 Years 5.6-29.0 mcg/L
Premenopausal  
35-45 Years 5.0-18.2 mcg/L
Pediatric Male (mcg/mL) Female (mcg/mL)
2-24 months* 25.4-124.0 25.4-124.0
25 months-5 Years Not established Not established
6-9 Years 41.0-134.6 41.0-134.6
10-13 Years 43.8-177.4 24.2-154.2
14-17 Years 13.7-128.0 10.5-75.2
*Pediatric data from Int J Biol Markers 1996; 11:159-164.


Methodology:
  • Immunoenzymatic

Clinical Significance

The Bone-Specific Alkaline Phosphatase (BSAP) assay provides a general index of bone formation and a specific index of total osteoblast activity. BSAP and osteocalcin are the most effective markers of bone formation and are particularly useful for monitoring bone formation therapies and antiresorptive therapies.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

1 to 2 days


Coding & Compliance

CPT Coding

84075