Caffeine

Overview

  • EPIC Code:
  • LAB706
  • Soft Test Code:
  • CAFFS
  • Send Out Test Code:
  • 305
Alternate Names
  • Caffeine Serum
  • Caffeine, Serum
  • Serum Caffeine
Clinical Significance

Coffee, tea and other beverages may contain caffeine. Caffeine is a methylxanthine found in over the counter products and in prescription medications. Small premature infants with mild respiratory distress shortly after birth may be treated with theophylline or caffeine. In neonates, a significant amount of theophylline is converted to caffeine. Since the demethylation pathway of theophylline is relatively undeveloped, caffeine levels may be elevated. Caffeine clearance rates typically reach adult values at about 3-4 months of age.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum from a Red Top Tube in a Plastic Vial 

Alternate Specimen

 

TransportAndStorage

5 days Ambient (Transport)
7 days Refrigerated

Collection Instructions

Collect as a trough just prior to next dose

Clinical Interpretation

Reference Range:

8.0-20.0 mg/L


Critical Ranges:

Potentially toxic: < 40 mcg/mL 

Lethal: 79-181 mcg/mL


Methodology:
  • Immunoassay (IA)

Clinical Significance

Coffee, tea and other beverages may contain caffeine. Caffeine is a methylxanthine found in over the counter products and in prescription medications. Small premature infants with mild respiratory distress shortly after birth may be treated with theophylline or caffeine. In neonates, a significant amount of theophylline is converted to caffeine. Since the demethylation pathway of theophylline is relatively undeveloped, caffeine levels may be elevated. Caffeine clearance rates typically reach adult values at about 3-4 months of age.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

2 to 5 days


Coding & Compliance

CDM

00910498


CPT Coding

80155