Cytomegalovirus IgG Avidity

Overview

  • EPIC Code:
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 19583
Alternate Names
  • CMV IgG Avidity
  • Cytomegalovirus (CMV) IgG Avidity (AviDx), ELISA
Clinical Significance

Discrimination between recent (primary) and past cytomegalovirus (CMV) infection can be an important tool in the clinical management of transplant recipients and pregnant women. Although nearly all individuals with recent CMV infection are positive for CMV IgM, individuals with past CMV may also express CMV IgM, following viral reactivation; thus, detection of CMV IgM is not a reliable indicator of recent infection. Measurement of CMV IgG avidity can assist in discriminating recent from past CMV infection. Although a low avidity index is a reliable indicator of CMV infection within the previous 6 months, a high avidity index is more meaningful from a clinical standpoint; a high avidity index essentially excludes the possibility that infection occurred within the previous 4 months


Specimen Collection & Preparation

Specimen Requirements

0.5 mL Serum from a Red Top Tube in a Plastic Vial

Alternate Specimen

0.5 mL Serum in a SST Gold Top Tube

TransportAndStorage

7 days Ambient (Transport)
14 days Refrigerated
30 days Frozen

Collection Instructions

Centrifuge and separate from cells immediately

Clinical Interpretation

Reference Range:

≥0.60


Methodology:
  • Immunoassay (IA)

Clinical Significance

Discrimination between recent (primary) and past cytomegalovirus (CMV) infection can be an important tool in the clinical management of transplant recipients and pregnant women. Although nearly all individuals with recent CMV infection are positive for CMV IgM, individuals with past CMV may also express CMV IgM, following viral reactivation; thus, detection of CMV IgM is not a reliable indicator of recent infection. Measurement of CMV IgG avidity can assist in discriminating recent from past CMV infection. Although a low avidity index is a reliable indicator of CMV infection within the previous 6 months, a high avidity index is more meaningful from a clinical standpoint; a high avidity index essentially excludes the possibility that infection occurred within the previous 4 months


Documentation

Laboratory Developed Test at Focus Diagnostics, Inc.


Production Schedule

Sites Performed
  • Quest - Chantilly to San Juan Capistrano
Days Performed
Sunday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

1 to 3 days


Coding & Compliance

CDM

00913333


CPT Coding

86644