Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism and follow-up for abnormal maternal serum alpha fetoprotein or maternal screening results.
AneuVysion may be run simultaneously with this test utilizing the same specimen.
20 mL fresh amniotic fluid submitted in sterile, nontoxic centrifuge tubes
1 day Ambient (transport/ship)
1 day Refrigerated
Unacceptable Frozen
Indicate the patient’s gestational age; reason for study and family history.
Designate if Alpha-Fetoprotein or Acetylcholinesterase tests are needed
30 mL is preferred if other testing, e.g., microarray, FISH, is ordered
5.0 mL amniotic fluid
See Interpretive Report
Amniotic fluid cells from two or more primary cultures are studied. G-banded metaphases are analyzed microscopically for numerical and structural abnormalities, and representative metaphases (minimum of 2) are karyotyped.
Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism and follow-up for abnormal maternal serum alpha fetoprotein or maternal screening results.
This test may be replaced by other Bill Codes, if the complete study cannot be performed, or if the specimen does not yield mitotically active cells for analysis (CPT(s): 88235, 88299).
6 to 8 days
88235, 88269, 88280