Activated Protein C Resistance

Overview

  • EPIC Code:
  • LAB2559
  • Soft Test Code:
  • APCR
  • Send Out Test Code:
  • 22
Alternate Names
  • Act Protein C Resist
  • Activated Protein C
  • Activated Protein C Resistance
  • APC Resistance, APCR
  • APC-R
Clinical Significance

Individuals with APC have a high risk for developing venous thrombosis.


Specimen Collection & Preparation

Specimen Requirements

2.0 mL Frozen Plasma from each of 2 Blue Top Tubes - 3.2% Na Citrate in a 2 Plastic Vials


Alternate Specimen

 


TransportAndStorage

60 days Frozen

Freeze immediately and ship on dry ice.


Collection Instructions

Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into four new plastic vials. Plasma must be free of platelets (<10,000/mcL). 

2 separate plastic vials 2.0 mL plasma frozen and sent  


Minimum Volume

1.0 mL Na Citrate Plasma x2


Neonatal Volumne

Clinical Interpretation

Reference Range:

> or = 2.1 Ratio


Methodology:
  • RVVT Based Assay (Clot-based)

Clinical Significance

Individuals with APC have a high risk for developing venous thrombosis.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 6 days


Coding & Compliance

CDM

00910594


CPT Coding

85307