Complement, Total

Overview

  • EPIC Code:
  • LAB154
  • Soft Test Code:
  • COMPT
  • Send Out Test Code:
  • 618
Alternate Names
  • CH 50
Clinical Significance

Total Complement (CH50) concentration is an overall measure of the complement system. Decreased concentrations are observed in patients with complement factor deficiencies and disease activity, e.g., systemic lupus erythematosus (SLE) and immune complex disease.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum in a SST Gold Top Tube

Alternate Specimen

1.0 mL Serum from a Red Top Tube in a Plastic Vial

TransportAndStorage

1 month Frozen

Collection Instructions

Avoid Hemolysis

Centrifuge and Separate within 1 hour of collection

Do not Thaw

Do not submit the sample in a glass tube

When ordered with other testing, must be in its own separate tube

Clinical Interpretation

Reference Range:

CH50: 31 - 66 U/mL

Detection Limit: 10 U/mL


Test Comments:

CH50 values below the reference range may indicate a deficiency in one or more of the components of complement. To obtain more definitive information, abnormal specimens should be assayed for levels of the individual components (C1 to C9).


Methodology:
  • Colorimetric

Clinical Significance

Total Complement (CH50) concentration is an overall measure of the complement system. Decreased concentrations are observed in patients with complement factor deficiencies and disease activity, e.g., systemic lupus erythematosus (SLE) and immune complex disease.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 6 days


Coding & Compliance

CDM

01425700


CPT Coding

86162