BCR/ABL: T(9;22)

Overview

  • EPIC Code:
  • LAB3235
  • Soft Test Code:
  • BCRFI
  • Send Out Test Code:
  • 5265-4
Alternate Names
  • BCR/ABL: T(9;22) by FISH
  • Philadelphia Chromosome Analysis
Clinical Significance

FISH for BCR/ABL is used to diagnose CML, is a prognostic indicator for B-cell Lymphoblastic Leukemia/Lymphoma, and is used to monitor patient response to tyrosine kinase inhibitor therapy. Before initiating treating with a TKI it may be helpful to order ABL Kinase analysis in order to better inform on which TKI to utilize.

 


Specimen Collection & Preparation

Specimen Requirements

5.0 mL Bone Marrow in Green Top Tubes - Na Heparin

Alternate Specimen

2.0 mL Peripheral Blood in a Green Top Tub - Na Heparin
or
2.0 mL Peripheral Blood in Lavendar Top Tube - EDTA

TransportAndStorage

72 hours Refrigerated

  Specimen has a 72 hour stability.  Specimens must arrive at PRMC in the Sendout Department by 4 p.m. if collected on a Friday.

Collection Instructions

Place bone marrow (2 ml req.) into tube, label with patient's name. Send in bone marrow kit 


Clinical Interpretation

Reference Range:

Refer to Interpretive Results


Methodology:
  • Fluorescence in situ Hybridization (FISH)

Clinical Significance

FISH for BCR/ABL is used to diagnose CML, is a prognostic indicator for B-cell Lymphoblastic Leukemia/Lymphoma, and is used to monitor patient response to tyrosine kinase inhibitor therapy. Before initiating treating with a TKI it may be helpful to order ABL Kinase analysis in order to better inform on which TKI to utilize.

 


Production Schedule

Sites Performed
  • GenPath Diagnostics
Departments
  • Sendouts - Genetics
Turn Around Time

3 to 5 days


Coding & Compliance

CPT Coding

88374