Cortisol, Free

Overview

  • EPIC Code:
  • LAB520
  • Soft Test Code:
  • CORF
  • Send Out Test Code:
  • 36423
Alternate Names
  • Cortisol Free
  • Cortisol, Free, LC/MS/MS
  • Free Cortisol
Clinical Significance

 Free cortisol is useful in the detection of patients with Cushing's syndrome for whom free cortisol concentrations are elevated.


Specimen Collection & Preparation

Patient Preparation

Patient should discontinue taking Biotin, Vitamin B7, or Vitamin H 48 hours before getting blood drawn.


Specimen Requirements

2.0 mL  Serum from a Red Top Tube in a Plastic Vial


Alternate Specimen

2.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial 


TransportAndStorage

4 hours Ambient
7 days Refrigerated (Transport)
2 years Frozen


Collection Instructions

 


Minimum Volume

0.7 mL


Neonatal Volumne

Clinical Interpretation

Reference Range:

Adult    
8:00 A.M.-10:00 A.M. 0.07-0.93 µg/dL
4:00 P.M.-6:00 P.M. 0.04-0.45 µg/dL
10:00 P.M.-11:00 P.M. 0.04-0.35 µg/dL


Test Comments:

Patients taking vitamin supplements containing high doses of biotin (>5 mg/day) may have falsely increased test results generated.


Methodology:
  • Equilibrium Dialysis
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

 Free cortisol is useful in the detection of patients with Cushing's syndrome for whom free cortisol concentrations are elevated.


Production Schedule

Sites Performed
  • Quest - Chantilly to San Juan Capistrano
Days Performed
Sunday
Wednesday
Departments
  • Sendouts - Clinical
Turn Around Time

8 Days


Coding & Compliance

CDM

00911039


CPT Coding

82530