Antiphospholipid Syndrome EvaluatR

Overview

  • EPIC Code:
  • LAB2571
  • Soft Test Code:
  • APEVG
  • Send Out Test Code:
  • 33693
Alternate Names
  • Anti-Phospholipid Eval
  • APS Evaluation
  • Habitual Aborter Panel
Included Tests

Beta-2-Glycoprotein I IgA Autoantibodies; Beta-2-Glycoprotein I IgG Autoantibodies; Beta-2-Glycoprotein I IgM Autoantibodies; Cardiolipin IgA Autoantibodies; Cardiolipin IgG Autoantibodies; Cardiolipin IgM Autoantibodies; dRVVT Screen with Reflex to dRVVT Confirm & dRVVT 1:1 Mix; Phosphatidylserine IgG Autoantibodies; Phosphatidylserine IgM Autoantibodies; 


Clinical Significance

Antiphospholipid antibodies are found in a wide range of conditions, either transiently as in some infectious diseases, or more persistently in autoimmune diseases such as SLE. Antiphospholipid antibodies are associated with fetal loss, endocarditis, stroke, heart attack and autoimmune hemolytic anemia.


Specimen Collection & Preparation

Specimen Requirements

1.0 mL Serum in a SST Gold Top Tube
and
2.0 mL Plasma from two (2) Blue Top Tubes 3.2% Sodium Citrate in Plastic Vials

Alternate Specimen

 

TransportAndStorage

Serum 
14 days Refrigerated

Plasma
14 days Frozen

Collection Instructions

1. First, Draw a plain red top tube to remove tissue fluid contamination. 
2. Draw blood into a buffered citrate collection tube (light blue top) filled to proper level. Do not overfill.
3. The blood-to-anticoagulant ratio should be 9:1; inadequate filling of the collection device will decrease this ratio and
may lead to inaccurate results.
4. Invert gently 6 times to mix. Process immediately.
5. Centrifuge for 15 min at 2500 x g.
6. Remove plasma using a plastic pipette to transfer into a Plastic Vial.
7. Repeat centrifugation at 2500 x g for 15 minutes to assure complete platelet removal.
8. Dispense the plasma into 2 or more plastic tubes using a plastic transfer pipette. Label tubes appropriately. 
9. Freeze immediately
10. Specimen must remain frozen at all times. 

Clinical Interpretation

Reference Range:

See Separate Report


Methodology:
  • Multiple - Based on Individual Components

Clinical Significance

Antiphospholipid antibodies are found in a wide range of conditions, either transiently as in some infectious diseases, or more persistently in autoimmune diseases such as SLE. Antiphospholipid antibodies are associated with fetal loss, endocarditis, stroke, heart attack and autoimmune hemolytic anemia.


Production Schedule

Sites Performed
  • Parkview Regional Medical Center
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Immunology
  • Sendouts - Clinical
Turn Around Time

6 to 10 days


Coding & Compliance

CPT Coding

85613, 86146 x 3, 86147 x 3, 86148 x 2