Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS

Overview

  • EPIC Code:
  • LAB3002
  • Soft Test Code:
  • ALDR
  • Send Out Test Code:
  • 16845
Alternate Names
  • Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
Included Tests

Aldosterone, Plasma Renin Activity; Aldosterone/Plasma Renin Activity Ratio


Clinical Significance

The Aldosterone-renin ratio is used to screen for primary aldosteronism


Specimen Collection & Preparation

Specimen Requirements:

-OR-

1.8 mL Frozen Plasma from a Lavender Top Tube - EDTA in a Plastic Vial
Minimum Volume:
0.8 mL plasma*

* This volume does not allow for repeat testing

Collection Instructions:

Collect a mid-morning blood sample after patient has been upright (sitting, standing, or walking) for a minimum of 2 hours

At 2 hours upright, have patient sit for 5 to 15 minutes prior to collection. 

Collect specimen. 


Processing Instructions:

Centrifuge and separate plasma from cells to plastic vial 

Freeze


Rejection Criteria:

Plasma collected in plasma separator tube (PST)

Moderate to gross hemolysis

Specimen received thawed


Transport and Storage:
  • Frozen (-20° C or colder): 28 Days

Clinical Interpretation

Reference Range:

Aldosterone

Adult    
Upright 8:00-10:00 A.M. ≤28 ng/dL
Upright 4:00-6:00 P.M. ≤21 ng/dL
Supine 8:00-10:00 A.M. 3-16 ng/dL
Pediatric    
1-12 Months 2-70 ng/dL
1-4 Years 2-37 ng/dL
5-9 Years ≤9 ng/dL
10-13 Years ≤21 ng/dL
14-17 Years ≤35 ng/dL
Infants    
Premature (31-35 Weeks) ≤144 ng/dL
Term ≤217 ng/dL
Tanner Stages    
II-III Males 1-13 ng/dL
II-III Females 2-20 ng/dL
IV-V Males 3-14 ng/dL
IV-V Females 4-32 ng/dL

 

Plasma Renin Activity 0.25-5.82 ng/mL/h
Aldosterone/PRA Ratio 0.9-28.9 Ratio


Methodology:
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)

Clinical Significance

The Aldosterone-renin ratio is used to screen for primary aldosteronism


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Clinical
Turn Around Time

5 to 7 days


Coding & Compliance

CDM

00913333


CPT Coding

82088, 84244