Alpha Melanocyte Stimulating Hormone

Overview

  • EPIC Code:
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 91898
Alternate Names
  • a-MSH
Clinical Significance

Alpha MSH is a 13 amino acid peptide (1665 kD) with serine at the N terminal end and amidated valine at the C terminal end. Alpha MSH is derived from pro-opiomelanocortin , a precursor protein which contains within its structure , the sequence of ACTH, beta MSH and gamma MSH. The aminoacid sequence of alpha MSH is identical to ACTH 1-13 in humans. Alpha MSH stimulates melanosome dispersion within dermal melanocytes and melanin biosynthesis within epidermal melanocytes .It also stimulates aldosterone synthesis. Plasma alpha MSH increases in human with high fever due to endotoxin. Average plasma alpha MSH has been found higher in AIDS patients and also in obese men with insulin resistance.


Specimen Collection & Preparation

Patient Preparation

Fasting Specimen is preferred. 
Patient should be freee from medications for 2 days.


Specimen Requirements

3.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial

Alternate Specimen

TransportAndStorage

6 hours Refrigerated
90 days Frozen

Collection Instructions

Clinical Interpretation

Reference Range:

Children: Up to  25 pg/ml
Adults: Up to 5.0 pg/ml


Methodology:
  • Enzyme Linked Immunosorbent Immunoassay (ELISA)
  • Extraction

Clinical Significance

Alpha MSH is a 13 amino acid peptide (1665 kD) with serine at the N terminal end and amidated valine at the C terminal end. Alpha MSH is derived from pro-opiomelanocortin , a precursor protein which contains within its structure , the sequence of ACTH, beta MSH and gamma MSH. The aminoacid sequence of alpha MSH is identical to ACTH 1-13 in humans. Alpha MSH stimulates melanosome dispersion within dermal melanocytes and melanin biosynthesis within epidermal melanocytes .It also stimulates aldosterone synthesis. Plasma alpha MSH increases in human with high fever due to endotoxin. Average plasma alpha MSH has been found higher in AIDS patients and also in obese men with insulin resistance.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Thursday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

4 to 7 days


Coding & Compliance

CDM

00913333


CPT Coding

83520