Last Modified:
6/20/2019 5:47:48 AM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
5.0 mL bronchial brush/wash collected in an Sterile Gray, leak-proof container
or
5.0 mL tracheal aspirate collected in an Sterile Gray, leak-proof container
or
5.0 mL Urine collected in an Sterile Gray, leak-proof container
Collection Instructions:
Minimum Volume:
3.0 mL wash • aspirate • urine
Transport & Storage: Temperature/Stability:
72 hours Ambient
7 days Refrigerated (transport)
Rejection Criteria:
Frozen • Specimen received in formalin and/or alcohol
Reference Range:
MTB ComplexNot detected
Rifampin ResistanceNot detected
Critical Ranges:
Test Comments:
Methodology:
Real-Time Polymerase Chain Reaction
Clinical Significance:
Globally, about 2 billion people are infected with MTB. In 2010, 8.8 million people developed active disease and 1.4 million people lost their lives to the illness. There were 9951 new cases of tuberculosis reported in the United States in 2012 (a rate of 3.2 cases per 100,000). In 2011, 536 deaths were attributed to tuberculosis infections.
Standard treatment regimens for tuberculosis involve prolonged administration of multiple drugs and is usually highly effective. However, MTB-complex strains that are resistant to one or more of first line drugs require individualized treatment. Rifampin resistance is often an indication of multidrug resistance to tuberculosis (MDR TB), which is defined as resistance to at least rifampin (RIF) and isoniazid (INH). In the Unites States overall RIF resistance is approximately 1.8% with approximately 90% of these strains resistant to at least RIF and INH
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
1 to 2 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed:
Quest - Chantilly
PHL Test Code:
MSOT
Send Out Test Code:
36925
Included Tests:
Mycobacterium tuberculosis complex DNA; Mycobacterium tuberculosis complex rpoB gene rifampin resistance mutation
CPT Coding:
87801
Go back to the top of the page.