LRP4 Autoantibody Test

Last Modified: 8/24/2021 6:49:04 AM


Specimen Requirements:

2.0 mL Serum from a SST Gold Top Tube
Collection Instructions: Please label each specimen tube with two forms of patient identification. These forms of identification must also appear on the requisition form
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 72 hours Ambient
25 days Refrigerated (Transport)
25 days Frozen
Reference Range: Refer to Interpretive Results
Methodology: Immunofluorescence Assay (IFA)
Clinical Significance: Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK
Documentation: Disease test for: Myasthenia Gravis (MG)
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 9 to 16 days
Sites Performed: Quest - Chantilly to Athena Labs
PHL Test Code: LRP4
EPIC Test Code: IMO5539
Send Out Test Code: 94744
CPT Coding: 86255

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