Sirolimus

Overview

  • EPIC Code:
  • LAB875
  • Soft Test Code:
  • SIRO
  • Send Out Test Code:
  • 36712
Alternate Names
  • Rapamune
  • Rapamycin
  • Sirolimus MonitR™
Clinical Significance

Immunosuppressive therapeutic drug monitoring to assess efficacy and potential toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is 72 hours; in females 61 hours.


Specimen Collection & Preparation

Specimen Requirements

3.0 mL Whole Blood in a Lavender Top Tube - EDTA


Transport And Storage

5 days Ambient
7 days Refrigerated (preferred)
30 days Frozen


Collection Instructions

 


Minimum Volume

1.0 mL Whole Blood


Neonatal Volume

Clinical Interpretation

Reference Range:

3.0 - 18.0 mcg/L


Methodology:
  • Liquid Chromatography / Tandem Mass Spectrometry (LC-MS/MS)
Clinical Significance

Immunosuppressive therapeutic drug monitoring to assess efficacy and potential toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is 72 hours; in females 61 hours.


Production Schedule

Sites Performed
  • Quest - Chantilly
Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Sendouts - Clinical
Turn Around Time

3 to 5 days


Coding & Compliance

CDM

00911166


CPT Coding

80195