Porphobilinogen, Quantitative 24-hour Urine

Last Modified: 8/21/2023 1:43:03 PM


Medical Necessity Documentation:  
Client Notes: Please contact 266-1500 option 1 to notify them you will need a special collection kit sent to your local hospital for your patient to pick up.
Patient Preparation: Whenever possible, the specimen should be collected during an acute episode because porphobilingen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. Twenty-four hour specimens should be refrigerated and protected from UV light during collection. PBG is most stable at pH 6-7, but samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data
Specimen Requirements: 2.0 mL aliquot from a well mixed 24 hour Urine Collection in a Plastic Container, aliquoted into 2 amber vials.
Collection Instructions:

1. When starting the 24-hour period, urinate and discard (throw-away) this specimen. NOTE THE TIME
2. From that time on, collect all urine by urinating into a clean container and transfer into the provided container. 
DO NOT URINATE DIRECTLY INTO CONTAINER.
3. Try to pass the last urine just prior to the end of the 24 hour period. Add this urine into the container. 
4. Urine Specimen should be kept refrigerated during and after collection. 

Urine must be Refrigerated & Protected from Light through collection (as long as specimen is in the 24-hr Jug it is protected from the light)

For patient collection instruction sheet see Addendum D
For Spanish patient collection instruction sheet see Addendum D
For Burmese patient collection instruction sheet see Addendum D
For Arabic patient collection instruction sheet see Addendum D
Minimum Volume: 1.0 mL Urine
Transport & Storage: Temperature/Stability: 7 days Refrigerated when pH of 6-7
30 days Frozen when pH of 6-7
Rejection Criteria: Not Protected from Light; Ambient
Reference Range:
Pediatric Not established
Adult <0.34 mg/24 h

Critical Ranges:  
Test Comments:  
Methodology: Chromatography/Mass Spectrometry
Clinical Significance:  
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 2 to 5 days
Days Performed: Tuesday, Thursday, Saturday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: PORP1
EPIC Test Code: LAB2556
Send Out Test Code: 726
Alternate Test Names: PBG; Porphobilinogen 24 Hr Urine
Included Tests:  
CPT Coding: 84110

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