Medicare Medical Necessity Restrictions May Apply
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
1.0 mL Serum from a SST Gold Top Tube
Collection Instructions:
Mix by inverting tube 5 times.
Separate serum from cells ASAP or within 2 hours of collection
Minimum Volume:
0.5 mL Serum
Transport & Storage: Temperature/Stability:
After separation from cells:
48 hours Ambient
2 weeks Refrigerated
1 year Frozen
Rejection Criteria:
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Reference Range:
0.9 IV or Less: Negative - No significant level of Treponema pallidum IgG antibody detected.
1.0 IV: Equivocal - Questionable presence of Treponema pallidum IgG antibody detected. Repeat testing in 10-14 days may be helpful.
1.1 IV or Greater: Positive - Presence of IgG antibody to Treponema pallidum detected, suggestive of current or past infection.
Critical Ranges:
Test Comments:
Interpretive Data:
Seroconversion between acute and convalescent sera is considered strong evidence of recent infection. The best evidence for infection is a significant change on two appropriately timed specimens, where both tests are performed in the same laboratory at the same time. The Treponema pallidum Antibody, Particle Agglutination (TP-PA), Serum (28060) is recommended for follow-up of reactive nontreponemal tests for syphilis, and as a single test in patients suspected of late syphilis. For CSF specimens, the VDRL test (28062) is recommended.
Methodology:
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Clinical Significance:
May be used as a primary syphilis screening test in reverse screening algorithm. The CDC recommends a nontreponemal test (RPR or VDRL) for initial syphilis screening prior to confirmation with a treponemal test (eg, TP-PA).
Documentation:
ARUP recommends, syphilis screening test in so-called reverse screening algorithm. The CDC recommends a nontreponemal test (RPR or VDRL) for initial syphilis screening prior to confirmation with a treponemal test (eg, TP-PA).
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
3 to 9 days
Days Performed:
Wednesday
Sites Performed:
ARUP Lab
PHL Test Code:
MSOT
EPIC Test Code:
Send Out Test Code:
0050920
Alternate Test Names:
Syphilis Antibody, IgG; Syphilis Antibody, IgG by ELISA; T pallidum IgG ELISA; Treponema pallidum Antibody, IgG by ELISA, Serum
Included Tests:
CPT Coding:
86780