Last Modified:
9/20/2022 3:04:49 PM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Patients should fast overnight and refrain from consuming fish or other seafood the day before the blood draw to avoid false elevations in TMAO
Specimen Requirements:
1.0 mL Serum from a SST Gold Top Tube
Collection Instructions:
1. Gently invert 5X immediately after draw (DO NOT SHAKE!).
2. Allow blood to clot for 30 minutes at room temperature.
3. Centrifuge for 10 minutes.
4. Store and transport refrigerated.
Minimum Volume:
0.5 mL Serum
Transport & Storage: Temperature/Stability:
1 day Ambient
7 days Refrigerated (Transport)
193 days Frozen at -20° & -70°
Rejection Criteria:
Specimens other than serum; improper labeling; samples not stored properly; samples older than stability limits; hemolyzed specimens
Reference Range:
<6.2 uM
Critical Ranges:
Test Comments:
Methodology:
LCTMS
Clinical Significance:
Gut microbes live symbiotically within the human digestive tract and play important roles in host defense, immunity, and nutrient processing and absorption. This diverse community is unique to each person and influenced by both acute and chronic dietary exposures to various food sources. Nutrients such as phosphatidylcholine (also known as lecithin), choline, and L-carnitine are abundant in animal-derived products such as red meat, egg yolk and full-fat dairy products. When consumed, these nutrients are processed by gut bacteria resulting in the release of various metabolites including TMA (trimethylamine) into the blood. TMA is then transported to the liver where it is converted into TMAO (trimethylamine N-oxide) which has been shown to regulate various physiological processes involved in the development of atherosclerosis.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
5 to 6 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed:
Cleveland HeartLab
PHL Test Code:
TMAO
EPIC Test Code:
LAB3095
Send Out Test Code:
C524
Alternate Test Names:
TMAO; TMAO (Trimethylamine N-oxide); Tri N-Oxide
Included Tests:
CPT Coding:
83520
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