Protein C, Antigen

Last Modified: 10/5/2022 11:17:20 AM


Medical Necessity Documentation: Recommended as outpatient testing only
Client Notes:  
Patient Preparation:  
Specimen Requirements:

1.0 mL Platelet Poor Plasma from a Blue Top Tube - 3.2% Na Citrate in a Plastic Vial
Collection Instructions:
Draw blood in light blue-top tube containing 3.2% sodium citrate, and mix gently by inverting 3-4 times. 
Centrifuge 15 minutes at 1500 x g within 1 hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet
buffy layer and place into a plastic vial. 
Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). 
Freeze immediately and transport on dry ice
Minimum Volume: 0.5 mL Platelet Poor Plasma
Transport & Storage: Temperature/Stability:

Unacceptable Ambient
Unacceptable Refrigerated
14 days Frozen
30 days Frozen at -70°
Rejection Criteria: Gross hemolysis
Reference Range: 70-140% of normal 
Critical Ranges:  
Test Comments: Conditional comment will appear on reports when result is < 70% of normal (decreased): Decreased levels of Protein
C Antigen may be found in congenital deficiency, treatment with oral anticoagulants, liver disease, D.I.C., and post surgery.
Methodology: Enzyme Immunoassay
Clinical Significance: Aids in diagnosis of congenital deficiencies characterized by recurrent venous thrombosis. Acquired deficiencies associated with Protein C include: oral anticoagulant therapy, liver disease, vitamin K deficiency, malignancy, consumptive DIC, surgery, trauma, antibodies to Protein C and hepatic immaturity of the newborn.
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 to 6 days
Days Performed: Monday, Tuesday, Wednesday, Thursday, Friday
Sites Performed: Quest - Chantilly
PHL Test Code: PCAG
EPIC Test Code: IMO203
Send Out Test Code: 19673 / 4948X
Alternate Test Names: Protein C, Ag
Included Tests:  
CPT Coding: 85302

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