Drug Monitoring, Methamphetamine D/L Isomers, Urine

Last Modified: 12/21/2022 8:54:28 AM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:  20 mL random urine collected in a clinical drug test transport vial.
Collection Instructions:  
Minimum Volume: 5 mL
Transport & Storage: Temperature/Stability: Transport at room temperature.
Stability ambient 5 days; refrigerated 14 days; frozen 30 days
Rejection Criteria: Preserved samples
Reference Range:  See laboratory report.
Critical Ranges:  
Test Comments:  
Methodology: Chromatography / Mass Spectrometry
Clinical Significance: This test measures the ration of the d and L isomers of methamphetamine in urine.  Methamphetamine isomers are biomarkers to identifywhich forms of methamphetamine are present.  The test is a definitive drug assay using the liquid chromatography/mass spectrometry (LC/MS-MS) method of analysis.  Methamphetamine is a stimulant drug of abuse as well as a prescription drug used to treat attention deficit hyperactivity disorder (ADHD) and obesity.  Methamphetamine has two isomer forms, D and L.  The L isomer is used in over-the-counter nasal decongestant products and is also a metabolite of the drug selegiline.  The D isomer is used for prescription methamphetamine and is also a metabolite of the drug benzphetamine.  Illicit methamphetamine formulations are primarily the D form.  Approximately 62% of an oral dose is excreted with ~33% as unchanged drug and ~66% metabolites (including amphetamine)
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 3 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Departments:
Sites Performed: Quest - Chantilly
PHL Test Code: MAMPU
EPIC Test Code: LAB3225
Send Out Test Code: 39413
Included Tests:  
CPT Coding: 80374

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