Tacrolimus, Highly Sensitive

Overview

  • EPIC Code:
  • IMO477
  • Soft Test Code:
  • PROGF
Alternate Names
  • FK506
  • Prograf
  • Tacrolimus
Clinical Significance

Tacrolimus (FK 506) is an immunosuppresive drug used in organ transplantation to prevent graft rejection.Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.


Specimen Collection & Preparation

Specimen Overview

Specimen must be kept capped before tested and needs to be tested within 30 minutes of the cap being open.

Specimen Requirements:

-OR-

3.0 mL Whole Blood in a Lavender Top Tube - EDTA
Collection Instructions:

Drug regimens, time and date of drug administration are to be noted on requisition. Therapeutic range applies to trough specimens drawn just before AM dose.

Optimal time to draw specimen: 0.5 - 1 hour before next oral dose.

Whole Blood collected in Lavender top tube must fill at least 1/3 of the collection tube.


Rejection Criteria:

Clotted specimen

Gel barrier tube


Transport and Storage:
  • Ambient (18-24°C): 5 Days
  • Refrigerated (2-8°C): 7 Days

    Preferred

  • Frozen (-20° C or colder): 3 Months

Clinical Interpretation

Reference Range:

5.0 - 20.0 ng/mL


Methodology:
  • Electrochemiluminescence (ECLIA)
Clinical Significance

Tacrolimus (FK 506) is an immunosuppresive drug used in organ transplantation to prevent graft rejection.Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.


Production Schedule

Sites Performed
  • Parkview Regional Medical Center
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Chemistry
Turn Around Time

1 to 2 days


Coding & Compliance

CDM

01420197


CPT Coding

80197