Vitamin K is a required cofactor for the synthesis of factors 2, 7, 9, and 10, and proteins C and S. Deficiencies of vitamin K lead to bleeding. Warfarin acts as an anticoagulant because it is a vitamin K antagonist.
Fasting for a minumum of 8 hours required.
Patient should refrain from eating liver and taking multivitamins or vitamin K at least 24 hours before sample collection.
1.0 mL Frozen Plasma from a Lavender Top Tube - EDTA in a Amber Vial
24 hours Ambient
24 hours Refrigerated
3 months Frozen (Transport)
Do not thaw
Samples received frozen but not protected from light are acceptable.
Centrifuge within 1 hour of collection, transfer plasma into amber vial, freeze immediately
Protect from Light by placing the plasma in an Amber Vial or other in the dark protocols
If unable to centrifuge immediately, sample should be covered with aluminum foil (or amber specimen bag) immediately and placed on ice until plasma or serum can be separated from cells
0.5 mL Plasma
130 - 1500 pg/mL
Vitamin K is a required cofactor for the synthesis of factors 2, 7, 9, and 10, and proteins C and S. Deficiencies of vitamin K lead to bleeding. Warfarin acts as an anticoagulant because it is a vitamin K antagonist.
3 to 4 days
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