Thioridazine and Metabolite

Overview

  • EPIC Code:
  • Soft Test Code:
  • MSOT
  • Send Out Test Code:
  • 4461SP
Alternate Names
  • Mellaril
Included Tests

Mesoridazine; Thioridazine


Specimen Collection & Preparation

Specimen Requirements

2.0 mL Plasma from a Lavender Top Tube - EDTA in a Plastic Vial


Transport And Storage

8 days Ambient (Preferred)
8 days Refrigerated
1 year Frozen


Collection Instructions

Do not collect in a Serum Separator Tube (SST or PST)


Minimum Volume


Neonatal Volume

Clinical Interpretation

Reference Range:

Mesoridazine 
Trough: 100 - 1400 ng/mL 
Reporting Limit: 100 ng/mL

Thioridazine 
Trough: 140 - 2400 ng/mL
Reporting Limit: 100 ng/mL.


Critical Ranges:

Mesoridazine: 1500 ng/mL or more  
Thioridazine: 2400 ng/mL or more


Test Comments:

Steady-state serum concentration during chronic oral administration of 400 mg daily is 140-2600 ng/mL. 

Therapeutic steady-state concentrations may overlap levels associated with toxicity. 

Toxicity may be present at concentrations which overlap with therapeutic levels observed with high dose therapy.


Methodology:
  • Gas Chromatography (GC)

Production Schedule

Days Performed
Monday
Tuesday
Wednesday
Thursday
Friday
Departments
  • Sendouts - Miscellaneous
Turn Around Time

6 to 10 days


Coding & Compliance

CPT Coding

84022