Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG and IgM

Last Modified: 5/11/2023 8:55:42 AM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:  1.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:

Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. 
  Mark specimens plainly as "acute" or "convalescent." 
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 48 hours Ambient
2 weeks Refrigerated
1 year Frozen

Avoid Thaw/Freeze Cycles

 
Reference Range:
HSV 1 and/or 2 Abs, IgM by ELISA: 0.89 IV or less


Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG by Chemiluminescent Immunoassay
Interpretation 
0.89 IV or less: Not Detected.
0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected.
 
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgM by ELISA
Interpretation
0.89 IV or less: Not Detected.
0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected - IgM antibody to HSV detected, which may indicate a current or recent infection. 
However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection. 
Critical Ranges:  
Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Chemiluminescent Immunoassay
Clinical Significance:  
Documentation:

 Not recommended for herpes simplex virus (HSV) testing; IgM lacks adequate predictive value for acute infection. If pursuing antibody testing, preferred test is Herpes Simplex Type 1 and Type 2 Glycoprotein G-Specific Antibodies, IgG by CIA (0051152). If acute HSV infection is suspected, molecular testing is preferred, refer to Herpes Simplex Virus (HSV-1/HSV-2) Subtype by PCR (2010095).
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 1 to 2 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: ARUP Lab
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: 0050291
Alternate Test Names: HSV 1 and 2; HSV 1 and 2 antibody panel; HSV 1, 2; HSV 1, 2, IgG IgM
Included Tests:  
CPT Coding: 86694 x2

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