Last Modified:
6/14/2019 1:08:48 PM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
1.0 mL Serum in a SST Gold Top Tube
Collection Instructions:
Transport & Storage: Temperature/Stability:
21 days Refrigerated (preferred/transport)
60 days Frozen
Rejection Criteria:
Received Ambient; Gross hemolysis, gross lipemia, or gross icterus
Reference Range:
< 140% Baseline
Critical Ranges:
Test Comments:
Please note: A serum TSH level >350 micro-International Units/mL can interfere with the TSI bioassay, and potentially give higher TSI results.
Methodology:
In Vitro Bioassay
Clinical Significance:
Graves' disease is a classic form of hyperthyroid disease, affecting approximately 0.4% of the population in the United States. It is caused by IgG immunoglobulins, collectively known as thyroid stimulating immunoglobulins (TSI). Patients who are candidates for antithyroid drug therapy may not respond to this treatment when TSI levels are markedly elevated. The determination of TSI can also assist in predicting hyperthyroidism in neonates, due to placental transmission of the immunoglobulins from a mother with hyperthyroidism.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
5 to 8 days
Days Performed:
Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed:
Quest - Chantilly
PHL Test Code:
TSHIM
EPIC Test Code:
LAB746
Send Out Test Code:
30551
Alternate Test Names:
TSI
Included Tests:
CPT Coding:
84445
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