Last Modified:
10/30/2023 10:12:57 AM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
1.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:
Minimum Volume:
1.0 mL Serum
Transport & Storage: Temperature/Stability:
72 hours Ambient
14 days Refrigerated (Transport-Cold Packs)
30 days Frozen
Rejection Criteria:
Serum separator tubes (SST) • Other body fluids • Other specimen types
Reference Range:
Target for prophylaxis purpose: trough level greater than 0.7 mcg/mL after 7 days of treatment.
Target for salvage treatment: trough level greater than 1.25 mcg/mL after 7 days of treatment.
Critical Ranges:
Test Comments:
Methodology:
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Clinical Significance:
The antifungal drug posaconazole is indicated for prophylaxis of invasive aspergillus and candida infections in severely immunocompromised patients. It may also be used in the treatment of oropharyngeal candidiasis refractory to itraconazole and fluconazole. The chronic nature of fungal infections demands constant monitoring of posaconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
2 to 5 days
Days Performed:
Tuesday, Thursday, Saturday
Sites Performed:
Quest - Chantilly to Quest Lewisville
PHL Test Code:
POSA
EPIC Test Code:
LAB3302
Send Out Test Code:
94010
Alternate Test Names:
Antifungal Posaconazole, LC/MS/MS; Noxafil ®
Included Tests:
CPT Coding:
80187
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