Prostate Specific Antigen, Free and Total

Overview

  • EPIC Code:
  • LAB171
  • Soft Test Code:
  • PSFT
Alternate Names
  • Fractionated PSA
  • Free PSA and Total PSA
  • PSA Free and Total
  • PSA II
  • PSA, Free and Total
  • T/F PSA
Included Tests

% Free PSA calculated ; PSA Free; PSA Total


Clinical Significance

In men over 50 years with total PSA between 4.0 and 10.0 ng/mL, the percent (%) free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % free PSA may aid in avoiding unnecessary biopsies.

Elevated levels of Prostate Specific Antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.


Specimen Collection & Preparation

Patient Preparation

 Patient should discontinue taking Biotin, Vitamin B7, or Vitamin H 48 hours before getting blood drawn


Specimen Requirements:

-OR-

2.0 mL Serum in a SST Gold Top Tube
Minimum Volume:
1.0 mL Serum*

* This volume does not allow for repeat testing

Collection Instructions:

Do not collect specimen after a transrectal biopsy, results may be falsely elevated


Rejection Criteria:

Gross hemolysis

Gross lipemia

Grossly icteric


Transport and Storage:
  • Refrigerated (2-8°C): 5 Days
  • Frozen (-20° C or colder): 3 Months

Clinical Interpretation

Reference Range:

Refer to Interpretive Report


Test Comments:

Patients taking vitamin supplements containing biotin doses of > 5 mg/day may have falsely decreased test results generated.


Methodology:
  • Electrochemiluminescence (ECLIA)
Clinical Significance

In men over 50 years with total PSA between 4.0 and 10.0 ng/mL, the percent (%) free PSA gives an estimate of the probability of cancer. In these circumstances the measurement of the % free PSA may aid in avoiding unnecessary biopsies.

Elevated levels of Prostate Specific Antigen (PSA) have been associated with benign and malignant prostatic disorders. Studies indicate that in men 50 years or older measurement of PSA is a useful addition to the digital rectal exam in the early detection of prostate cancer. In addition, PSA decreases to undetectable levels following complete resection of the tumor and may rise again with recurrent disease or persist with residual disease. Thus, PSA levels may be of assistance in the management of prostate cancer patients.


Production Schedule

Sites Performed
  • Parkview Regional Medical Center
Days Performed
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Departments
  • Chemistry
Turn Around Time

Same day/next day


Coding & Compliance

CPT Coding

84153, 84154


Medical Necessity May Apply