Myelin Oligodendrocyte Glycoprotein Antibody with Reflex to Titer

Last Modified: 12/31/2020 10:04:39 AM


Specimen Requirements:

2.0 mL Serum from a Red Top Tube in a Plastic Vial
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 7days Ambient
14 days Refrigerated (transport)
21 days Frozen
Rejection Criteria: Serum Separator Tube (SST) • Visible particulate matter
Reference Range:
MOG Ab CBA, Serum Negative
  MOG Ab Titer, Serum <1:10 titer
Test Comments: If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86256).
Methodology: Cell-based Immunofluorescence Assay
Clinical Significance: Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, Serum - Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 5 to 9 days
Days Performed: Wednesday
Sites Performed: Quest - Chantilly to San Juan Capistrano
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: 36952
Alternate Test Names: ADEM antibody; LETM antibody; MOG; MOG Ab; MOG IgG; NMO Spectrum Disorder; NMOSD; Optic Neuritis Antibody; Transverse Myelitis Antibody
CPT Coding: 86255

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