Topiramate is an antidepressant used as an adjunctive treatment of partial-onset epilepsy and Lennox-Gastaut syndrome in children. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
2.0 mL Serum from a Red Top Tube in a Plastic Vial
7 days Ambient (transport)
14 days Refrigerated
31 days Frozen
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady state
Trough levels are more reproducible than peak levels.
Order must include the as to whether it is a Trough, Peak or Random specimen
1.0 mL
|
Dosage / mg
|
Peak mcg/mL
|
Trough mcg/mL
|
|
100
|
6.5 - 9.2
|
4.5 - 6.6
|
|
200
|
12.0 - 16.00
|
8.0 - 12.0
|
|
400
|
20.0 - 30.0
|
14.0 - 20.0
|
Pediatric patients have 50% higher clearance and shorter elimination half-life than adults. Consequently, plasma levels for the same dosage will be lower than for adults.
Topiramate is an antidepressant used as an adjunctive treatment of partial-onset epilepsy and Lennox-Gastaut syndrome in children. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
2 to 4 Days
00910201
80201