Last Modified:
8/7/2023 12:51:37 PM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
2.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady state
Trough levels are more reproducible than peak levels.
Order must include the as to whether it is a Trough, Peak or Random specimen
Minimum Volume:
1.0 mL
Transport & Storage: Temperature/Stability:
7 days Ambient (transport)
14 days Refrigerated
31 days Frozen
Rejection Criteria:
Gel Barrier Tubes (SST/PST)
Reference Range:
|
Dosage / mg
|
Peak mcg/mL
|
Trough mcg/mL
|
|
100
|
6.5 - 9.2
|
4.5 - 6.6
|
|
200
|
12.0 - 16.00
|
8.0 - 12.0
|
|
400
|
20.0 - 30.0
|
14.0 - 20.0
|
Critical Ranges:
Test Comments:
Pediatric patients have 50% higher clearance and shorter elimination half-life than adults. Consequently, plasma levels for the same dosage will be lower than for adults.
Methodology:
Chromatography/Mass Spectrometry
Clinical Significance:
Topiramate is an antidepressant used as an adjunctive treatment of partial-onset epilepsy and Lennox-Gastaut syndrome in children. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
2 to 4 Days
Days Performed:
Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed:
Quest - Chantilly
PHL Test Code:
TOPIR
EPIC Test Code:
LAB498
Send Out Test Code:
30965
Alternate Test Names:
Topiramate
Included Tests:
CPT Coding:
80201
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