Chromosome Analysis, Tissue

Last Modified: 10/25/2021 12:31:33 PM

  Medicare Medical Necessity Restrictions May Apply
Client Notes:
Patient Preparation:  
Specimen Requirements:
3 mm Tissue in sterile container w/ Hanks' or Ringers solution or Culture Medium w/ Antibiotics (Contact 266-1502 option 1 to request appropriate solution)

Skin: Forearm Sample
Miscarriages Material: 
Fetal             3mm
Sac               3mm
Cord             3mm
Placenta      3mm
Inner Muscle    3mm
Lung                  3mm
Kidney               3mm
Skin                   3mm
Heart                 3mm
Collection Instructions: Patient clinical history and reason for referral are required with test order.

Approximately 50% of first trimester spontaneous abortuses have abnormal karyotypes. This test is useful to determine cause of miscarriage and recurrence potential. Submitted placental and/or fetal tissue is cultured. When available, at least 20 G-banded metaphases are examined microscopically for numerical and structural abnormalities and representative metaphases (minimum of 2) are karyotyped.

As products of conception can be contaminated or be necrotic by the time of collection, tissue culture may be unsuccessful. Another approach is the study of parental karyotypes from peripheral blood for potential balanced abnormalities that may be heritable in unbalanced forms. This is generally recommended for couples who have experienced three or more spontaneous losses
Minimum Volume: 2 - 3 mm
Transport & Storage: Temperature/Stability: Transport Refrigerated

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.
Rejection Criteria: Formalin Fixed; Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Reference Range:

Refer to Interprative Results

Critical Ranges:  
Test Comments:  
Methodology: Tissue Culture, Karyotype, Microscopy
Clinical Significance:

Autosomal or sex chromosome mosaicism not detected in lymphocytes may be determined in fibroblasts obtained from a tissue biopsy.
Cells from organ biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is of questionable viability.
Fetal tissues or extra embryonic membranes are frequently used to diagnose fetal chromosome abnormalities that are associated with approximately one-half of all first trimester spontaneous abortions.

Custom Panel: No


Turn Around Time: 15 days
Days Performed: Sunday, Monday, Tuesday, Wednesday, Thursday, Friday, Saturday
Sites Performed: Quest - Chantilly
PHL Test Code: CHRTI
EPIC Test Code: LAB3134
Send Out Test Code: 14593
Alternate Test Names: Chromosome Analysis, Tissue ; Chromosome, Tissue; Karyotype; Karyotype, Tissue; Tissue Chromosome; Tissue Chromosome, Qualitative
Included Tests:  
CPT Coding: 88233, 88262, 88291

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