TPMT Enzyme

Last Modified: 11/11/2023 9:31:44 AM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 5.0 mL Whole Blood in a Lavender Top Tube - EDTA
Collection Instructions:  Do not collect Friday or Saturday
Transport & Storage: Temperature/Stability:

8 days Refrigerated
Reference Range:

Normal TPMT Activity: >21.0 EU/mL
Intermediate TPMT Activity: 6.0-21.0 EU/mL
Low TPMT Activity: <6.0 EU/mL
Critical Ranges:  
Test Comments:  
Methodology: .
Clinical Significance:

PROMETHEUS

® TPMT Enzyme testing provides a quantitative analysis of a patient’s thiopurine methyltransferase (TPMT) enzyme activity level. Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT enzyme phenotype may reduce time of response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Departments:
Sites Performed: Prometheus
PHL Test Code: MSOT
EPIC Test Code:
Send Out Test Code: 3320
Alternate Test Names: Thiopurine Methyltransferase RBC; TPMT Enzyme; TPMT Enzyme (Phenotype)
Included Tests:  
CPT Coding: 84433

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