Last Modified:
11/1/2022 6:53:37 AM
Medical Necessity Documentation:
Client Notes:
Patient Preparation:
Specimen Requirements:
3.0 mL Serum from a Red Top Tube in a Plastic Vial
Collection Instructions:
Minimum Volume:
1.5 mL Serum
Transport & Storage: Temperature/Stability:
7 days Ambient
31 days Refrigerated
60 days Frozen
Rejection Criteria:
Serum Separator Tube (SST)
Reference Range:
Mean steady-state serum levels of risperidone + OH-risperidone following daily regimens:
2 mg/day-14 ng total active drug/mL
6 mg/day-45 ng total active drug/mL
10 mg/day-73 ng total active drug/mL
16 mg/day-110 ng total active drug/mL
Critical Ranges:
Methodology:
Gas Chromatography Mass Spectrometry
Clinical Significance:
Therapeutic drug monitoring for effective therapy. Risperidone is rapidly converted into its hydroxy metabolite in the liver. Peak concentration of Risperidone occurs in about 1 hour following oral administration and for 9-hydroxyrisperidone the peak level is reached at 3 hours (17 hours for poor metabolizers). The elimination half-life of Risperidone is 3 hours (20 hours for poor metabolizers), and is 21 hours of hydroxyrisperidone (30 hours for poor metabolizers). Notes: Risperidone and OH-Risperidone are approximately equally effective; therefore, the sum of their concentrations is reported as total active drug.
Documentation:
Custom Panel:
No
PRODUCTION SCHEDULE
Turn Around Time:
1 to 4 days
Days Performed:
Tuesday, Thursday, Saturday
Sites Performed:
Quest - Valencia
PHL Test Code:
MSOT
EPIC Test Code:
MISC
Send Out Test Code:
14365
Alternate Test Names:
Risperadol
Included Tests:
CPT Coding:
80299
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