Proteinase-3 Autoantibodies

Last Modified: 5/22/2019 4:25:15 PM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements:

1.0 mL Serum in a SST Gold Top Tube
Collection Instructions:  
Minimum Volume: 0.5 mL Serum
Transport & Storage: Temperature/Stability: 48 hours Refrigerated
30 days Frozen


Specimen to be transported Refrigerated to PRMC within 48 hours of collection to be frozen by Immunology department to maintain specimen integrity until testing occurs. Do not transport Frozen.
Reference Range: < 20 Units
Critical Ranges:  
Test Comments:  
Methodology: EIA
Clinical Significance: PR-3 is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) which give a cytoplasmic (C-ANCA) immunofluorescence pattern. Elevated levels of PR-3 autoantibodies are classically observed in patients with Wegener granulomatosis (WG), particularly with active disease and less frequently in other forms of necrotizing vasculitis
Documentation:  
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 7 days
Days Performed: Tuesday
Sites Performed: Parkview Regional Medical Center
PHL Test Code: PR3
EPIC Test Code: IMO2154
Alternate Test Names: C-ANCA
Included Tests:  
CPT Coding: 86021

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