Leukotriene E4, 24-Hour Urine

Last Modified: 3/2/2022 6:46:05 AM


Medical Necessity Documentation:  
Client Notes:  
Patient Preparation:  
Specimen Requirements: 5.0 mL Urine from a well mixed 24-hr Urine in a Plastic Vial
Collection Instructions: No preservatives 

1. When starting the 24-hour period, urinate and discard (throw-away) this specimen. NOTE THE TIME
2. From that time on, collect all urine by urinating into a clean container and transfer into the provided container. 
DO NOT URINATE DIRECTLY INTO CONTAINER.
3. Try to pass the last urine just prior to the end of the 24 hour period. Add this urine into the container. 
4. Urine Specimen should be kept refrigerated during and after collection. 

For patient collection instruction sheet see Addendum D
For Spanish patient collection instruction sheet see Addendum D
For Burmese patient collection instruction sheet see Addendum D
For Arabic patient collection instruction sheet see Addendum D
Minimum Volume: 2.0 mL Urine
Transport & Storage: Temperature/Stability:

24 hours Ambient
7 days Refrigerated (Preferred)
30 days Frozen
Reference Range: Leukotriene E4:

< or =104 pg/mg creatinine


Creatinine: 

Normal values mg per 24 hours:

Males: 930-2955 mg/24 hours

Females: 603-1783 mg/24 hours
Critical Ranges:  
Test Comments:

Elevated urinary leukotriene E4 (LTE4) concentrations greater than104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.

 

Urinary LTE4 may be used together with serum tryptase, urinary 2,3-dinor 11 beta-prostaglandin F2 alpha, and/or urinary N-methyl histamine
Methodology: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) & Enzymatic Colorimetric Assay
Clinical Significance:  An aid to evaluate patients suspected of having systemic mastocytosis using 24-hour urine collections
Documentation:  Reference values have not been established for patients who are less than 18 years of age.
Custom Panel: No

PRODUCTION SCHEDULE

Turn Around Time: 2 to 6 days
Days Performed: Tuesday, Friday
Sites Performed: Mayo Laboratory
PHL Test Code: MSOT
EPIC Test Code: MISC
Send Out Test Code: TLTE4
Alternate Test Names: Cysteinyl Leukotriene; LTE4; Mast Cell Activation Syndrome; Mastocytosis; Systemic Mast Cell Activation
Included Tests: Creatinine; Leukotriene E4
CPT Coding: 82542

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