Autoimmune Thrombocytopenic Purpura (AITP) is one of the most common causes of immune thrombocytopenia. A diagnosis of AITP is usually reached by excluding nonimmune causes of thromcytopenia such as sepsis, fever, acute leukemia, and drug-induced thrombocytopenia. Approximately 85% of AITP patients have elevations of Platelet Associated IgG (PAIgG), PAIgM or both. The majority of these antibodies react with platelet surface membrane glycoproteins
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Blood Center Requisition for PLT Ab testing
40.0 mL Whole Blood in five Yellow Top Tubes - ACD-A
4 days Refrigerated
Collect Monday through Thursday Only - Must be sent same day as collection
Patient Platelet Count < 100,000 per mm to Volume of Whole Blood 40.0 mL
Patient Platelet Count > 100,000 per mm to Volume of Whole Blood 10.0 mL
10.0 mL
Negative - ELISA values less than twice the normal control values
Positive - ELISA values greater than twice the normal control values
Positive or negative results should be used in conjunction with clinical findings and other test results to establish diagnosis. Autoantibodies present at reduced levels, as in AITP responsive to therapy, may be missed in this assay. This assay detects only antibodies reactive with platelet GPIIb/IIIa, GPIb/IX and GPIa/IIa. Human anti-mouse antibodies may be detected, causing false positive results.
Samples from patients recently transfused may reflect characteristics of donor, rather than patient, platelets. If the patient has been transused, wait 4 days before drawinging sample. If the patient is receiving continous platelet transusion draw sample immediately before next transfusion. Steroids or IVIg do not affect testing.
Autoimmune Thrombocytopenic Purpura (AITP) is one of the most common causes of immune thrombocytopenia. A diagnosis of AITP is usually reached by excluding nonimmune causes of thromcytopenia such as sepsis, fever, acute leukemia, and drug-induced thrombocytopenia. Approximately 85% of AITP patients have elevations of Platelet Associated IgG (PAIgG), PAIgM or both. The majority of these antibodies react with platelet surface membrane glycoproteins
4 to 7 days
86022, 86023